Essential PPIase that regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity.
Displays a preference for an acidic residue N-terminal to the isomerized proline bond.
Catalyzes pSer/Thr-Pro cis/trans isomerizations.
Down-regulates kinase activity of BTK.
Can transactivate multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation.
Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation.
Applications:Suitable for use in ELISA and Western Blot.
Other applications not tested.
Recommended Dilution:ELISA: 1:128,000Western Blot: 0.2-0.6ug/ml, observed in rat brain lysates on ~17kD bandsOptimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for at least 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
Host：goat
Source Antibody：rat
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.
Specificity：Recognizes rat PIN1. Species sequence homology: Canine, human and mouse.
Isotype：IgG
Calc Applications Abbrev：E WB
Calc Crossreactivity：Ca Hu Mo Rt
Immunogen：Synthetic peptide corresponding to C-KHSQSRRPSSWRQEKITR, from rat PIN1, at the internal region of the protein (NP_006212.1).
