PI3KC2A belongs to the phosphoinositide 3-kinase (PI3K) family.
PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking.
This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases.
C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions.
The PI3-kinase activity of this protein is not sensitive to nanomolar levels of the inhibitor wortmanin.
This protein was shown to be able to be activated by insulin and may be involved in integrin-dependent signaling.
Applications:Suitable for use in ELISA and Immunohistochemistry Other applications not tested.
Recommended Dilution:ELISA: 1:32,000Immunohistochemistry (Paraffin): 5-10ug/mlOptimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for at least 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
Host：goat
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.
Specificity：Recognizes human PIK3C2A. Species sequence homology: Canine and mouse.
Isotype：IgG
Calc Applications Abbrev：E IHC
Calc Crossreactivity：Ca Hu Mo
Immunogen：Synthetic peptide corresponding to C-TVKWYQLTAATYL, from human PIK3C2A, at C-terminal (NP_002636.2).
