PDE11A is a 100kD cyclic nucleotide phosphodiesterase, which catalyzes the hydrolysis of cAMP and cGMP.
PDE11A is thought to be involved in multiple physiological processes in various organs.
PDE11A is calmodulin dependent and exists as four splice variants (PDE11A1-PDE11A4).
Mutations in this gene are a cause of Cushing disease and adrenocortical hyperplasia.
Applications:Suitable for use in ELISA and Western Blot.
Other applications not tested.
Recommended Dilution:ELISA: 1:2000Western Blot: 0.5-1.5ug/ml, observed in human skeletal muscle and prostate lysates on ~60-65kD bandsOptimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for at least 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
Host：goat
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.
Specificity：Recognizes human PDE11A. Species sequence homology: Canine, mouse and rat.
Isotype：IgG
Calc Applications Abbrev：E WB
Calc Crossreactivity：Ca Hu Mo Rt
Immunogen：Synthetic peptide corresponding to C-NSFKESMEKSSYSD, from human PDE11A, at the internal region of the protein (NP_058649.3, NP_001070665.1).
