NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium.
Mediated by glycine.
In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage.
Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death.
Applications:Suitable for use in ELISA and Western Blot.
Other applications not tested.
Recommended Dilution:ELISA: 1:16,000Western Blot: 2-4ug/ml, observed in rat brain lysates on ~170kD bandsOptimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for at least 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
Host：goat
Source Antibody：rat
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in Tris saline, pH 7.3, 0.5% BSA, 0.02% sodium azide.
Specificity：Recognizes rat GRIN2B.
Isotype：IgG
Calc Applications Abbrev：E WB
Calc Crossreactivity：Rt
Immunogen：Synthetic peptide corresponding to C-KDAHEKDDFHHLS, from rat GRIN2B, at the internal region of the protein (NP_000825.1). Species sequence homology: canine, human and mouse
![NMDAR2B (Glutamate [NMDA] Receptor Subunit epsilon-2, N-methyl D-aspartate Receptor Subtype 2B, NMDAR2B, NR2B, N-methyl-D-aspartate Receptor Subunit 3, NR3, hNR3, GRIN2B) 100ug](https://aimg.as-1.co.jp/c/84/1227/66/85133520.jpg)