84-1226-07　LAX1 (Lymphocyte Transmembrane Adapter 1, Linker for Activation of X Cells, Membrane-associated Adapter Protein LAX, LAX) 100ug　L1440-01

特徴

• LAX1 (Linker for activation of X cells) is a 70kD member of a small group of T cell transmembrane (TM) adaptor proteins.
• It is upregulated on both T and B cells after activation, and likely downmodulates both BCR and TCR signaling.
• Human LAX1 is 398aa in length.
• Although its predicted MW is 44kD, it runs anomalously at 70kD in SDS-PAGE.
• It is a type III (no signal sequence) TM protein that contains a 37aa N-terminal extracellular region and a 340aa cytoplasmic domain (aa59-398).
• There are two potential isoform variants.
• One has an alternate start site at Met77, while a second shows a 13aa substitution for aa1-29.
• Over aa136-398, human LAX1 is 47% aa identical to mouse LAX1.
• Applications:Suitable for use in ELISA.
• Other applications not tested.
• Recommended Dilution:ELISA: 1:1000Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for at least 12 months.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.