SET2 is a histone methyltransferase that methylates 'Lys-36' of histone H3.
H3 'Lys-36' methylation represents a specific tag for epigenetic transcriptional activation.
This protein probably plays a role in chromatin structure modulation during elongation via its interaction with hyperphosphorylated POLR2A.
SET2 binds DNA at promoters, and may act as a transcription activator.
SET2 binds to the promoters of adenovirus 12 E1A gene in case of infection, possibly leading to regulate its expression.
Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin.
SET2 belongs to a class of huntingtin interacting proteins characterized by WW motifs.
Applications:Suitable for use in ELISA and Western Blot.
Other applications not tested.
Recommended Dilution:ELISA: 1:4000Western Blot: 0.5-2ug/mlOptimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for at least 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
Host：goat
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.
Specificity：Recognizes mouse SETD2. Species sequence homology: Human.
Isotype：IgG
Calc Applications Abbrev：E WB
Calc Crossreactivity：Hu Mo
Immunogen：Synthetic peptide corresponding to C-ERDPDKQTQNKE, from SETD2, at the internal region of the protein (NP_054878.3).
