G-protein coupled receptor 83 (GPR83, GIR, GPR72, KIAA1540), a 423aa protein, is an orphan member of GPCR protein family and is closely related to tachykinin and NPY receptors.
It is a human homolog of mouse GIR protein and is exclusively expressed and selectively up-regulated in brain.
It is a cell surface receptor protein consisting of a putative seven-transmembrane-domain.
Reports suggest GPR83 might be involved in the regulation of immune tolerance mechanism by inducing peripheral generation of Foxp3+ Treg cells.
Applications:Suitable for use in ELISA and Western Blot.
Other applications not tested.
Recommended Dilution:ELISA: 1:8000Western Blot: 1-3ug/ml, human, mouse and rat brain lysates observed on ~48kD bandsOptimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for at least 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
Host：goat
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.
Specificity：Recognizes human GPR83. Species Crossreactivity: mouse and rat. Species sequence homology: canine, porcine and bovine.
Isotype：IgG
Calc Crossreactivity：Bo Ca Hu Mo Po Rt
Immunogen：Synthetic peptide corresponding to C-RRYGAESQNPTVK, from the internal region of human GPR83 (NP_057624.3).
