G-protein coupled receptor 83 (GPR83, GIR, GPR72, KIAA1540), a 423aa protein, is an orphan member of GPCR protein family and is closely related to tachykinin and NPY receptors.
It is a human homolog of mouse GIR protein and is exclusively expressed and selectively up-regulated in brain.
It is a cell surface receptor protein consisting of a putative seven-transmembrane-domain.
Reports suggest GPR83 might be involved in the regulation of immune tolerance mechanism by inducing peripheral generation of Foxp3+ Treg cells.
Applications:Suitable for use in ELISA and Western Blot.
Other applications not tested.
Recommended Dilution:ELISA: 1:2000Western Blot: 1-3ug/ml, human brain (cerebellum, cerebral cortex and amygdala) lysates observed on ~50kD bandsOptimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for at least 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
Host：goat
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.
Specificity：Recognizes human GPR83.
Isotype：IgG
Calc Applications Abbrev：E WB
Calc Crossreactivity：Hu
Immunogen：Synthetic peptide corresponding to TEPHEGRADEQSAE-C, from human GPR83, at N-terminal (NP_057624.3).
