GnRHR is a Releasing-Hormone Receptor activated by gonadotropin-releasing hormone (GnRH).
This receptor plays a major role in the regulation of reproductive functions.
It modulates the synthesis and secretion of gonadotropin hormones such as luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from the pituitary.
In turn, LH and FSH regulate the release of steroid hormones from the gonads.
Mutations in GnRHR have been linked to hypogonadotropic hypogonadism, a condition characterized by absence or delayed puberty and retarded bone maturation.
GnRHR has been reported to be expressed mostly in the pituitary gonadotropes and in reproductive organs, including ovary, placenta, prostate, testis, and uterus.
It is also expressed in breast, heart, kidney, liver, skeletal muscle, and thymus.
No human ESTs have been isolated for this receptor.
Applications:Suitable for use in ELISA and Western Blot.
Other applications not tested.
Recommended Dilution:ELISA: 1:32,000Western Blot: 0.5-1.5ug/ml, observed in human lysates of peripheral blood mononucleocytes on ~60kD bandsOptimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for at least 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
Host：goat
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.
Specificity：Recognizes human GNRHR. Species sequence homology: Canine.
Isotype：IgG
Calc Applications Abbrev：E WB
Calc Crossreactivity：Ca Hu
Immunogen：Synthetic peptide corresponding to C-QKWTQKKEKGK, from human GNRHR, at the internal region of the protein (NP_000397.1, NP_001012781.1).
