84-1224-53　GSTM1, GSTM2 (Glutathione S-transferase Mu 1, GST HB Subunit 4, GST Class-mu 1, GSTM1-1, GSTM1a-1a, GSTM1b-1b, GTH4, GST1 / Glutathione S-transferase Mu 2, GST Class-mu 2, GSTM2-2, GST4) 100ug　G8135-38A

特徴

• Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families.
• At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta.
• This gene encodes a glutathione S-transferase that belongs to the mu class.
• The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione.
• The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic.
• These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs.
• Null mutations of this class mu gene have been linked with an increase in a number of cancers, likely due to an increased susceptibility to environmental toxins and carcinogens.
• Multiple protein isoforms are encoded by transcript variants of this gene.
• Applications:Suitable for use in ELISA and Western Blot.
• Other applications not tested.
• Recommended Dilution:ELISA: 1:1000Western Blot: 1-3ug/ml, observed in human liver lung lysates on ~26kD bandsOptimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for at least 12 months.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.