84-1224-07　FXR (Farnesoid X-activated Receptor, Bile Acid Receptor, Farnesol Receptor HRR-1, BAR, HRR-1, Nuclear Receptor Subfamily 1 Group H Member 4, NR1H4, Retinoid X Receptor-interacting Protein 14, RXR-interacting Protein 14, RIP14) 100ug　F9300-01B

特徴

• Farnesoid X-activated receptor (FXR, HRR-1, BAR, RIP14; NR1H4) is a member of the orphan nuclear receptor family.
• FXR is expressed in the liver, intestinal villi, renal tubes and adrenal cortex.
• FXR is a global regulator of bile acid metabolism.
• Two genes, cholesterol 7a-hydroxylase (CYP7A1) and IBABP (ileal bile acid binding protein), which are implicated in bile acid biosynthesis and recycling, respectively, are target genes of FXR.
• FXR is shown to be transcriptionally activated by farnesol metabolites such as farnesol itself and juvenile hormone III.
• FXR binds to DNA only as a heterodimer with RXR.
• Applications:Suitable for use in ELISA and Western Blot.
• Other applications not tested.
• Recommended Dilution:ELISA: 1:32,000Western Blot: 1-3ug/ml, observed in human duodenum and lung lysates on ~55kD bandsOptimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for at least 12 months.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.