This gene belongs to the forkhead family of transcription factors which is characterized by a distinct DNA-binding forkhead domain.
It plays a role in the differentiation of lung epithelium.
May also play a role in developing neural, gastrointestinal and cardiovascular tissues. Defects in FOXP2 are the cause of speech-language disorder 1 (SPCH1); also known as autosomal dominant speech and language disorder with orofacial dyspraxia.
Affected individuals have a severe impairment in the selection and sequencing of fine orofacial movements, which are necessary for articulation.
Applications:Suitable for use in ELISA, Western Blot and Immunohistochemistry.
~85kD band observed in Human Brain (Cerebellum and Frontal Cortex) lysates and in Rat Brain lysates (MW 82.6kD)
Immunohistochemistry (Paraffin): 2-4ug/mlOptimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
Host：goat
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in Tris saline, pH 7.3, 0.5% BSA, 0.02% sodium azide.
Specificity：Recognizes human FOXP2. Species Crossreactivity: rat
Isotype：IgG
Calc Applications Abbrev：E IHC WB
Calc Crossreactivity：Hu Rt
Immunogen：Synthetic peptide corresponding to C-DEVEYQKRRSQKIT, from the internal region of human FOXP2. Species sequence homology: Bovine, canine, feline, mouse and porcine.
