Critical factor essential for ovary differentiation and maintenance, and repression of the genetic program for somatic testis determination.
Prevents trans-differentiation of ovary to testis through transcriptional repression of the Sertoli cell-promoting gene SOX9 By similarity.
Has apoptotic activity in ovarian cells.
Suppresses ESR1-mediated transcription of PTGS2/COX2 stimulated by tamoxifen.
Is a regulator of CYP19 expression.
Participates in SMAD3-dependent transcription of FST via the intronic SMAD-binding element.
Is a transcriptional repressor of STAR.
Activates SIRT1 transcription under cellular stress conditions.
Activates transcription of OSR2.
Applications:Suitable for use in ELISA and Western Blot.
Other applications not tested.
Recommended Dilution:ELISA: 1:8000Western Blot: 1-3ug/ml, observed in human ovary lysates on ~50kD bandsOptimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for at least 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
Host：goat
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.
Specificity：Recognizes human FOXL2. Species sequence homology: Bovine, mouse and rat.
Isotype：IgG
Calc Applications Abbrev：E WB
Calc Crossreactivity：Bo Hu Mo Rt
Immunogen：Synthetic peptide corresponding to C-DSKTGALHSRLDL, from human FOXL2, at C-terminal (NP_075555.1).
