FGFR1, also known as fibroblast growth factor receptor 1, is a receptor membrane tyrosine kinase belonging to the protein kinase superfamily, Tyr protein kinase family and fibroblast growth factor receptor subfamily with three Ig-like C2-type (immunoglobulin-like) domains and a protein kinase domain.
This enzyme acts as a receptor for basic fibroblast growth factor while a shorter form of the receptor could be a receptor for FGF1 (aFGF).
Binding of FGFR1 is reported to play a role in the modulation of bone elongation and also in bone development and maintenance.
It also mediates two independent signaling pathways in retinal pigment epithelial cells and regulates proliferation, differentiation, and maintenance of normal myocardium.
Defects in FGFR1 are responsible for several diseases which include Pfeiffer syndrome (PS), idiopathic hypogonadotropic hypogonadism (IHH), Kallmann syndrome type 2 (KAL2), osteoglophonic dysplasia (OGD), non-syndromic trigonocephaly and many more diseases.
Applications:Suitable for use in ELISA, Western Blot and Immunohistochemistry.
Other applications not tested.
Recommended Dilution:ELISA: 1:32,000Western Blot: 0.3-1ug/ml, observed in human breast lysates on ~75kD bandsImmunohistochemistry (Paraffin): 4-6ug/mlOptimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for at least 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
Host：goat
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.
Specificity：Recognizes human FGFR1. Species sequence homology: Bovine and canine.
Isotype：IgG
Calc Applications Abbrev：E IHC WB
Calc Crossreactivity：Bo Ca Hu
Immunogen：Synthetic peptide corresponding to CLPRHPAQLANGGLKR, from human FGFR1, at C-terminal (NP_075598.2, NP_056934.2).
