Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility.
Acts in assocation with DOCK1 and CRK.
Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases.
May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.
Applications:Suitable for use in ELISA, Immunohistochemistry and Western Blot.
Other applications not tested.
Recommended Dilution:ELISA: 1:32,000Western Blot: 1-3ug/ml, human brain lysate observed on ~80kD bandsImmunohistochemistry (paraffin): 3-6ug/mlOptimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for at least 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
Host：goat
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.
Specificity：Recognizes human ELMO2. Species sequence homology: Bovine, canine, mouse, porcine and rat.
Isotype：IgG
Calc Applications Abbrev：E IHC WB
Calc Crossreactivity：Bo Ca Hu Mo Po Rt
Immunogen：Synthetic peptide corresponding to C-PKEPSSYDFVYHYG, from human ELMO2, at C-terminal (NP_877496.1, NP_573403.1).
