The EGR2 gene provides instructions for making a protein called early growth response 2, which is part of the early growth response family of proteins.
These proteins bind to specific areas of DNA and help control the activity of particular genes.
On the basis of this action, the proteins are referred to as transcription factors.
The early growth response 2 protein activates several genes that are involved in the formation and maintenance of myelin, the fatty substance that covers and protects nerve cells.
Myelin promotes the efficient transmission of nerve impulses.
If myelin is lost (demyelination) or its structure is disrupted, the transmission of nerve impulses is impaired.
Mutations in the EGR2 gene can cause two forms of Charcot-Marie-Tooth disease, type 1D or type 4E (sometimes called congenital hypomyelinating neuropathy) or a severe form of type 1D (sometimes called Dejerine-Sottas syndrome) that begins during infancy or early childhood.
Applications:Suitable for use in ELISA, Western Blot and Immunohistochemistry.
Other applications not tested.
Recommended Dilution:ELISA: 1:64,000Western Blot: 0.03-0.1ug/ml, observed in lysates of cell line HepG2 on ~55kD bandsImmunohistochemistry (Paraffin): 3-5ug/mlOptimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for at least 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
Host：goat
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.
Specificity：Recognizes human EGR3. Species sequence homology: Canine, mouse and rat.
Isotype：IgG
Calc Applications Abbrev：E IHC WB
Calc Crossreactivity：Ca Hu Mo Rt
Immunogen：Synthetic peptide corresponding to HGTAGPDRKPFPC, from human EGR2, at the internal region of the protein (NP_000390.2).
