CXCR3 is a G protein-coupled receptor with selectivity for three chemokines, termed IP10, Mig and I-TAC.
The protein is mainly expressed on activated Th1 cells, B cells and natural killer cells.
It is activated by the interferon-gamma-inducible chemokines CXCL9, CXCL10 and CXCL11, with CXCL11 having the highest affinity.
Upon activation, CXCR3 activates pertussis toxin-sensitive G proteins of the Galphai class and mediates, among others, chemotaxis, calcium flux and activation of kinases such as p44/p42 MAPK and Akt.
The protein and its ligands are upregulated in a wide variety of inflammatory diseases, implying a role for CXCR3 in serious disorders (e.g.
rheumatoid arthritis, multiple sclerosis, transplant rejection, atherosclerosis and inflammatory skin diseases) and thus has attracted considerable attention as a drug target.
The gene encoding for human CXCR3 is localized in the chromosomal region Xq13.
Applications:Suitable for use in ELISA.
Other applications not tested.
Recommended Dilution:ELISA: 1:64,000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for at least 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
Host：goat
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.
Specificity：Recognizes CXCR3. Species sequence homology: Human, mouse and rat.
Isotype：IgG
Calc Applications Abbrev：E
Calc Crossreactivity：Hu Mo Rt
Immunogen：Synthetic peptide corresponding to C-RRDSSWSETSEA, from CXCR3, at C-terminal (NP_001495.1).
