It is an adaptor protein localized in the nucleus.
It interacts with the Alzheimer's disease amyloid precursor protein (APP), transcription factor CP2/LSF/LBP1 and the low-density lipoprotein receptor-related protein.
APP functions as a cytosolic anchoring site that can prevent the gene product's nuclear translocation.
This encoded protein could play an important role in the pathogenesis of Alzheimer's disease.
It is thought to regulate transcription.
Also it is observed to block cell cycle progression by downregulating thymidylate synthase expression.
Applications:Suitable for use in ELISA and Western Blot.
Other applications not tested.
Recommended Dilution:ELISA: 1:128,000Western Blot: 0.1-0.3ug/ml, observed in lysates of NIH/3T3 and HeLa on ~100kD bandsOptimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for at least 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
Host：goat
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.
Specificity：Recognizes APBB1. Species Crossreactivity: Human and mouse.
Isotype：IgG
Calc Applications Abbrev：E WB
Calc Crossreactivity：Hu Mo
Immunogen：Synthetic peptide corresponding to C-GSLKPKRLGAHTP, from APBB1, at C-terminal (NP_001155.1, NP_663722.1).
