TXNDC4/ERp44/KIAA0573 was identified via its interaction with Erol-Lalpha, which in turn has been shown to regulate oxidative protein folding by selectively oxidizing protein disulfide isomerase.
TXNDC4 is induced during ER stress and forms mixed disulfides with both hEROs and cargo folding intermediates.
Over expression has been shown to alter the equilibrium of the different Ero1-Lalpha redox isoforms suggesting that TXNDC4 may be involved in the control of oxidative protein folding.
It has also been suggested that TXNDC4 senses the environment in the ER lumen because it modulates IP3R1 (1,4,5-triphosphate receptor type 1) activity thereby regulating cytosolic calcium concentrations and intraluminal conditions.
Applications:Suitable for use in Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Immunohistochemistry (Formalin fixed paraffin embedded): 10-12.5ug/mlOptimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for at least 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, 0.09% sodium azide.
Specificity：Recognizes human ERP44.
Isotype：IgG
Calc Applications Abbrev：IHC
Calc Crossreactivity：Hu
Immunogen：Synthetic peptide corresponding to 18aa from the C-terminal domain of human ERP44.
