SHIP-1 p145 (SH2-containing-inositol phosphatase), an effector molecule, associates with activated Fms oncogenes.
SHIP-1 contains two phosphotyrosine-binding domains (PTB), a unique amino terminal SH2 domain, a proline-rich region, and two highly conserved motifs found among inositol phosphate 5-phosphatases.
SHIP-1 displays both phosphatidylinositol 3,4,5-triphosphate and inositol 1, 3, 4, 5 - tetrakisphosphate polyphosphate 5-phosphatase activity.
Evidence suggests that SHIP-1 may modulate Ras signaling in addition to inositol signaling pathways.
Applications:Suitable for use in Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Immunohistochemistry (Formalin fixed paraffin embedded): 1:50Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for at least 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：250ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in 10mM PBS, pH 7.4, BSA, sodium azide.
Specificity：Recognizes human INPP5D. Species sequence homology: mouse and rat.
Isotype：IgG
Calc Applications Abbrev：IHC
Calc Crossreactivity：Hu
Immunogen：Synthetic peptide corresponding to C-terminal of human SHIP-1.
