Plexin D1 is a type I transmembrane protein that is the prototype of the Plexin D subfamily in the Plexin family.
It is expressed on multiple tissues including fetal neuronal and endothelial cells.
Plexin D1 expression is also induced on tumor vasculature and tumor cells.
The 1879aa mature human Plexin D1 contains a large extracellular domain 1225aa with a 500aa sema domain and three short MRS (Met-related sequences) cysteine-rich motifs.
By alternative splicing, multiple Plexin-D1 isoforms may exist.
Plexin D1 binds Sema4A to suppress angiogenesis.
It also binds Sema3E directly to mediate repulsive vascular vessel guidance.
In mouse, this interaction has been shown to be independent of Neuropilin and Sema3A.
Over the extracellular region used as an immunogen, human Plexin D1 shares 89% and 91% aa identity with the mouse and canine protein.
Applications:Suitable for use in Flow Cytometry.
Other applications not tested.
Recommended Dilution:Optimal dilutions to be determined by the researcher.
Excitation: 488nm
Emission: 565-605nm
Storage and Stability:May be stored at 4°C before opening.
DO NOT FREEZE! Stable at 4°C as an undiluted liquid.
Dilute only prior to immediate use.
Stable for 12 months at 4°C.
Freezing R-Phycoerythrin (PE) conjugates will result in a substantial loss of activity.
PE conjugates are sensitive to light.
仕様
Size：100Tests
Host：goat
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in saline, 0.5% BSA, 0.09% sodium azide. Labeled with R-Phycoerythrin (PE).
Specificity：Recognizes human Plexin D1.
Isotype：IgG
Calc Applications Abbrev：FC
Calc Crossreactivity：Hu
Immunogen：Recombinant corresponding to aa47-1271 from human Plexin D1 to extracellular domain.
