84-1215-62　Cadherin R (Cadherin 4, Cadherin-4, Retinal Cadherin, CDH4, R-CAD, R-cadherin) 100ug　C0108-38A

特徴

• Cadherin-4 (also Retinal/R-Cadherin) is a 120kD (100kD predicted) member of the classical cadherin family of molecules.
• It is expressed on mammary epithelium, olfactory bulb neurons, cerebellar granule cells, vascular smooth muscle, astrocytes and pancreatic B-cells.
• Cadherin-4 forms both homodimers and heterodimers with N-cadherin.
• These complexes will oligomerize, providing sources for adhesion and migration.
• Cadherin-4 also binds to KLRG1 expressed on NK, T and Treg lymphocytes.
• Mouse cadherin-4 proprecursor is 893aa in length.
• It contains a 146aa propeptide aa21-166 coupled to a 746aa type I transmembrane mature protein aa 167-913.
• The mature region possesses a 565aa extracellular domain aa167-731 plus a 160aa cytoplasmic region aa753-913.
• Consistent with classical cadherins, cadherin-4 contains five cadherin repeats in the extracellular domain aa167-721.
• There is one potential splice form that shows a 44aa substitution for aa291-913.
• Over aa21-731, mouse cadherin-4 shares 98% and 93% aa identity with rat and human cadherin-4.
• Applications:Suitable for use in Western Blot and Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1ug/mlImmunohistochemistry: 5-15ug/mlOptimal dilutions to be determined by the researcher.
• Storage and StabilityLyophilized powder may be stored at -20°C.
• Stable for 12 months at -20°C.
• Reconstitute with sterile PBS.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Reconstituted product is stable for 12 months at -20°C.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
• Further dilutions can be made in assay buffer.