84-1213-70　TNFR2 (Tumor Necrosis Factor Receptor Superfamily Member 1B, Tumor Necrosis Factor Receptor 2, TNF-R2, Tumor Necrosis Factor Receptor Type II, TNF-RII, TNFR-II, p75, p80 TNF-alpha Receptor, CD120b, Etanercept, TNFRSF1B, TNFBR) 100ug　T9161-26K

特徴

• Tumor necrosis factor receptor 2 (TNFR2) is one of receptors of TNF.
• TNF has proinflammatory and immunosuppressive properties that may segregate at the level of the 2 TNF receptors (TNFRs), TNFR1 and TNFR2.
• The genes for TNFR1, a 55kD protein, and TNFR2, a 70kD protein, have been mapped to human chromosomes 12 (12pter-cen) and 1 (1pter-p32), respectively.
• TNFR2 was induced on glomerular endothelial cells of nephritic kidneys, and TNFR2 expression on intrinsic cells, but not leukocytes, was essential for glomerulonephritis and glomerular complement deposition.
• TNFR1 promotes systemic immune responses and renal T cell death, while intrinsic cell TNFR2 plays a critical role in complement-dependent tissue injury.
• Therefore, therapeutic blockade specifically of TNFR2 may be a promising strategy in the treatment of immune-mediated glomerulonephritis.
• Applications:Suitable for use in Western Blot and Immunohistochemistry.
• Other applications not tested.
• Recommended Dilutions:Western Blot: 0.1-0.5ug/mlImmunohistochemistry (Paraffin): 0.5-1ug/ml.
• Antigen retrieval by heat is recommended.
• Optimal dilutions to be determined by the researcher.
• Storage and Stability:Lyophilized powder may be stored at -20°C.
• Stable for 12 months at -20°C.
• Reconstitute with sterile ddH2O.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Reconstituted product is stable for 12 months at -20°C.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
• Further dilutions can be made in assay buffer.