The Toll-like receptor (TLR) family in mammal comprises a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and IL-1 receptor motif in the cytoplasmic domain.
Like its counterparts in Drosophila, TLRs signal through adaptor molecules (1).
The TLR family is a phylogenetically conserved mediator of innate immunity that is essential for microbial recognition (2).
TLR12 has been cloned that displays a distinct pattern of expression in macrophages and liver, kidney, and bladder epithelial cells.
TLR12 does not respond to known TLR ligands.
Applications:Suitable for use in Flow Cytometry and Western Blot.
Other applications not tested.
Recommended Dilutions:Western Blot: 1:100-1:2000Flow Cytometry: 1:10-1:1000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
Host：rabbit
Source Antibody：mouse
Grade：Affinity Purified
Purity：Purified by Protein G affinity chromatography.
Form：Supplied as a liquid in PBS, 0.2% gelatin, 0.05% sodium azide.
Specificity：Recognizes mouse TLR12. Species Crossreactivity: rat.
Isotype：IgG
Calc Applications Abbrev：FC WB
Calc Crossreactivity：Mo Rt
Immunogen：Synthetic peptide corresponding to aa743-756 (RVWLQGLRGKGDKG) of mouse TLR12.
