84-1211-82　［取扱停止］TIE1, CT (TIE-1, Tyrosine Protein Kinase Receptor, Tunica Internal Endothelial Cell Kinase) 50ul　T5498-65H

特徴

• TIE1/TIE (tyrosine kinase with Ig and EGF homology domains 1) and TIE2/Tek define a new class of the receptor tyrosine kinase (RTK) subfamily with unique structural characteristics: two immunoglobulin like domains flanking three epidermal growth factor (EFG) like domains followed by three fibronectin type III like repeats in the extracellular region and a split tyrosine kinase domain in the cytoplasmic region.
• Human TIE1 cDNA encodes a 1138aa residue precursor protein with a putative signal peptide, an extracellular domain, and a cytoplasmic domain.
• TIE1 and TIE2, expressed primarily on endothelial and hematopoietic progenitor cells, play important roles in angiogenesis, vasculogenesis, and hematopoiesis.
• In developing vascular endothelial cells, TIE1 and TIE2 are specifically expressed.
• Two ligands that bind TIE have been identified, angiopoietin 1 and angiopoietin 2.
• Based on gene targeting studies, the in vivo functions of TIE1 are related to endothelial cell differentiation.
• TIE1 is a receptor that is implicated in vessel maturation and angiogenesis.
• TIE1 contains immunoglobulin-like loops and epidermal growth factor (EGF) homology domains.
• Applications:Suitable for use in Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Immunohistochemistry (Formalin fixed paraffin embedded): 1:50 Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for at least 12 months.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.