84-1211-77　TRF2 (Telomeric Repeat-binding Factor 2, TTAGGG Repeat-binding Factor 2, Telomeric DNA-binding Protein, TERF2, TRBF2) 50ug　T2400-15B

特徴

• TRF2 is a ubiquitously expressed protein that is implicated in the control of telomere length.
• TRF2, like TRF1 contains a Myb-related DNA binding motif.
• It binds to duplex TTAGGG repeats and is localized to all human telomeres in metaphase chromosomes.
• TRF2 is thought to protect chromosome ends by maintaining the correct structure at telomere termini.
• The use of mutant forms of TRF2 has implicated a role for TRF2 in the prevention of senescence in primary human cells.
• Recently, it has been shown that inhibition of TRF2 resulted in apoptosis in a subset of mammalian cell types.
• Applications:Suitable for use in Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Immunohistochemistry (Formalin fixed paraffin embedded): 3.75ug/ml Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for at least 12 months.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.