84-1211-42　［取扱停止］RAIDD (Death Domain-containing Protein CRADD, Caspase and RIP Adapter with Death Domain, RIP-associated Protein with a Death Domain, CRADD) 50ug　R1032-02M

特徴

• Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms.
• Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain (DD)-containing receptors, TNFR1 and Fas.
• The death signals are transduced by a group of DD-containing adapter molecules.
• A novel cell death adapter was recently identified by two independent groups and designated RAIDD (RIP-associated ICH-1/CED-3-homologous protein with DD) and CRADD (caspase and RIP adapter with DD).
• RAIDD contains a DD and a CARD (for caspase recruitment domain) which interact with RIP and caspase, respectively, to transduce death signals.
• RAIDD is constitutively expressed in many tissues and mediates apoptosis caused by Fas and TNFR-1.
• Applications:Suitable for use in Western Blot and Immunohistochemistry.
• Other applications not tested.
• Recommended DilutionWestern Blot: 1:500Immunohistochemistry (Formalin fixed paraffin embedded): 10ug/ml Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for at least 12 months.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.