84-1211-06　［取扱停止］MCL1 (Induced Myeloid Leukemia Cell Differentiation Protein Mcl-1, Bcl-2-like Protein 3, Bcl2-L-3, Bcl-2-related Protein EAT/mcl1, mcl1/EAT, BCL2L3) 250ul　M2749-01J

特徴

• Mcl-1 (Myeloid cell leukemia-1) is a member of the bcl-2 family.
• The carboxy terminal of Mcl-1 and bcl-2 share significant sequence homology.
• Expression of Mcl-1 is increased upon exposure of ML-1 cells to various types of DNA damaging agents (e.g.
• ionizing radiation, ultraviolet radiation, and alkylating drugs) along with increases in GADD45 and Bax and a decrease in bcl-2.
• Like bcl-2, Mcl-1 has the capacity to promote cell viability under conditions that otherwise cause apoptosis.
• Myeloid cell leukimia-1 (Mcl-1) is a member of the Bcl-2 family of proteins that can act to promote cell survival.
• While the mechanism by which Mcl-1 inhibits apoptosis is not known, it is thought that it may heterodimerize and neutralize pro-apoptotic members of the Bcl-2 family such as Bim or Bak.
• Mcl-1 was originally identified in differentiating myeloid cells, but has since been shown to be expressed in multiple cell types.
• Mcl-1 is essential for embryogenesis and for the development and maintenance of B and T lymphocytes in animals.
• Mcl-1 exists as at least two distinct isoforms designated Mcl-1L and Mcl-1S.
• In marked contrast to the larger isoform of Mcl-1, overexpression of Mcl-1S promotes cell death.
• Applications:Suitable for use in Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Immunohistochemistry (Formalin fixed paraffin embedded): 1:25-1:100 Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for at least 12 months.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.