84-1210-81　［取扱停止］HINT1 (Histidine Triad Nucleotide-binding Protein 1, Adenosine 5'-Monophosphoramidase, Protein Kinase C Inhibitor 1, Protein Kinase C-interacting Protein 1, PKCI-1, HINT, PKCI1, PRKCNH1) 50ug　H4014-01

特徴

• Histidine triad nucleotide-binding protein 1 (HINT1) is a member of the histidine triad (HIT) protein family, a group of small nucleotide-binding and –hydrolyzing proteins.
• HINT1 interacts with several diverse proteins and has been suggested to have tumor suppressive activities.
• HINT1 catalyzes the hydrolysis of adenosine 5'-monophoramidate substrates such as AMP-morpholidate, but its enzymatic function does not appear to play a role in its tumor suppression.
• Recent experiments demonstrate that HINT1 forms a complex with POSH and JNK in vivo, inhibiting AP-1 activity and the phosphorylation of c-Jun, and this action could contribute to the tumor suppressor activity of HINT1.
• Other studies raise the possibility of HINT1 as a candidate gene for schizophrenia.
• Applications:Suitable for use in Western Blot and Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1-2ug/mlImmunohistochemistry (Formalin fixed paraffin embedded): 5ug/ml Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for at least 12 months.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.