84-1210-03　APP, NT (Amyloid beta A4 Protein, ABPP, APPI, Alzheimer Disease Amyloid Protein, Cerebral Vascular Amyloid Peptide, CVAP, PreA4, Protease Nexin-II, PN-II, A4, AD1) 50ug　A2275-87T2

特徴

• Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis.
• Involved in cell mobility and transcription regulation through protein-protein interactions.
• Can promote transcription activation through binding to APBB1-KAT5 and inhibits Notch signaling through interaction with Numb.
• Couples to apoptosis-inducing pathways such as those mediated by G(O) and JIP.
• Inhibits G(o) alpha ATPase activity.
• Acts as a kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1.
• Involved in copper homeostasis/oxidative stress through copper ion reduction.
• In vitro, copper-metallated APP induces neuronal death directly or is potentiated through Cu2+-mediated low-density lipoprotein oxidation.
• Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I and IV.
• The splice isoforms that contain the BPTI domain possess protease inhibitor activity.
• Induces a AGER-dependent pathway that involves activation of p38 MAPK, resulting in internalization of amyloid-beta peptide and leading to mitochondrial dysfunction in cultured cortical neurons.
• Applications:Suitable for use in Western Blot and mmunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1ug/mlImmunohistochemistry (Formalin fixed paraffin embedded): 1:50 Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for at least 12 months.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.