TIM-1 was first identified as the receptor used by hepatitis A for viral entry (it is also known as the hepatitis A virus cellular receptor- HAVCR).
TIM-1 is a key cell surface protein that binds TIM-4, leading to T cell proliferation and T helper type 2 (Th2) cytokine production.
TIM-1 has also been shown to bind and activate macrophages.
Two splice variants for human TIM-1 exist; TIM-1a is predominantly expressed in the liver, whilst TIM-1b is expressed in the kidney.
Expression of TIM-1 in the kidney is thought to be upregulated in damaged tissue, and is thought to assist healing.
TIM-1 polymorphisms are associated with asthma.
Applications:Suitable for use in Western Blot and Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Western Blot: 1-3ug/mlImmunohistochemistry (Formalin fixed paraffin embedded): 2.5-5ug/mlOptimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for at least 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by Protein G affinity chromatography.
Form：Supplied as a liquid in PBS, 0.05% BSA, 0.05% sodium azide.
Specificity：Recognizes human HAVCR1. Species sequence homology: Mouse
Isotype：IgG
Calc Applications Abbrev：IHC WB
Calc Crossreactivity：Hu
Immunogen：Synthetic peptide corresponding to aa200-300 of human HAVCR1.
