Members in the TNF superfamily regulate immune responses and induce apoptosis.
Two novel members in the TNF family were recently identified and designated BAFF/BLyS/TALL-1/THANK/zTNF4 and April/TALL-2, respectively.
BAFF was characterized as a B cell activator since it induced B cell proliferation and immunoglobulin secretion.
April regulates immunological and non-immunological cell growth.
Three receptors, BCMA, TACI, and BAFF-R, for BAFF and April were recently identified.
TACI, like BCMA, binds BAFF and April.
TACI and its ligands regulate humoral immune responses, activate NF-kB and c-jun N-terminal kinase, and are involved in B cell associated autoimmune diseases.
Applications:Suitable for use in Flow Cytometry, Western Blot and Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Western Blot: 5ug/mlImmunohistochemistry (Formalin fixed paraffin embedded): 5ug/mlOptimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for at least 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by Protein G affinity chromatography.
Form：Supplied as a liquid in PBS, 0.05% sodium azide, 0.2% gelatin.
Specificity：Recognizes human TACI. Species sequence homology: Mouse.
Isotype：IgG
Calc Applications Abbrev：FC IHC WB
Calc Crossreactivity：Hu
Immunogen：Synthetic peptide corresponding to aa116-132 of human TACI (KLH).
