PTP sigma, n R2B/LAR receptor protein tyrosine phosphatase, is composed of immunoglobulin and fibronectin type-III repeats, a single transmembrane domain and two intracellular catalytic phosphatase domains.
PTP sigma has been shown to affect neuronal development and differentiation, proliferation and/or adhesiveness of various cell types in the developing hypothalamo-pituitary axis, development of lung epithelium, and differentiation and development of the neuroendocrine system.
Mice lacking PTP sigma exhibit increased neuronatal fatality, stunted growth, developmental delays and severe neurological defects including spastic movements, tremor, ataxic gait, abnormal limb flexion and defective proprioception.
Increased expression of PTP sigma may be of pathogenetic significance for the defective insulin secretion in GK rat islets.
Two alternatively spliced protein isoforms of PTP sigma have been documented in humans, and the shorter isoform (1502aa) has been shown to expressed strongly in the brain.
Applications:Suitable for use in ELISA and Immunohistochemistry.
Other applications not tested.
Recommended Dilution:ELISA: 1:1000Immunohistochemistry (Formalin fixed paraffin embedded): 10ug/mlOptimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for at least 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by Protein G affinity chromatography.
Form：Supplied as a liquid in PBS, 0.09% sodium azide.
Specificity：Recognizes human PTPRS.
Isotype：IgG
Calc Applications Abbrev：E IHC
Calc Crossreactivity：Hu
Immunogen：Synthetic peptide corresponding to aa1350-1367 of human PTPRS (KLH).
