PAK7 (p21-activated protein kinase 7), a serine/threonine kinase, is a member of the PAK family of protein kinases.
PAK family members function as components of signaling modules that also include MAPK and the Rho family of small GTPases and are implicated in the regulation of cell motility and morphology.
PAK7, predominantly expressed in brain, is found to promote neurite outgrowth and thus may play a role in neurite development.
PAK7 associates with microtubule networks and induces microtubule stabilization.
PAK7 subcellular localization is tightly regulated during cell cycle progression.
PAK7 is characterized by the presence of a CDC42/Rac1 interactive binding (CRIB) motif at its N-terminus and a aa20-homologous domain at its C-terminus.
Applications:Suitable for use in Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Immunohistochemistry (Formalin fixed paraffin embedded): 5ug/mlOptimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for at least 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, 0.09% sodium azide.
Specificity：Recognizes human PAK7. Species sequence homology: Mouse (72/83%).
Isotype：IgG
Calc Applications Abbrev：IHC
Calc Crossreactivity：Hu
Immunogen：Synthetic peptide corresponding to internal domain of human PAK7 (KLH).
