Rev-erbA beta, a NR1 Thyroid Hormone-Like Receptor, has been shown to affect cell proliferation, organ physiology, and myogenesis.
Rev-erbA beta has been shown to be a constitutive repressor and binds as a monomer or homodimer to target DNA, such as the n-myc gene.
Rev-erbA beta has also been shown to repress the human apoCIII gene, therefore underscoring a physiological role in the regulation of genes involved in triglyceride metabolism and the pathogenesis of atherosclerosis.
Two isoforms of Rev-erbA beta have been isolated in rats (Rev-erbA beta 1 and Rev-erbA beta 2).
Rev-erbA beta 2 is longer than Rev-erbA beta 1 by 195aa.
Rev-erbA beta expression has been documented in animal brain, skeletal muscle, embryo, and spleen, and in human skeletal muscle.
ESTs have been isolated from human tissue libraries, including cancerous brain, colon, eye, kidney, lung, prostate, skin, and uterus, and normal brain, colon, embryo, heart, kidney, liver, lung, nerve, pineal, placenta, skeletal muscle, testis, tonsil, and uterus.
Applications:Suitable for use in Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Immunohistochemistry (Formalin fixed paraffin embedded): 10ug/mlOptimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for at least 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, 0.09% sodium azide.
Specificity：Recognizes human REVB. Species sequence homology: Mouse and rat (100%).
Isotype：IgG
Calc Applications Abbrev：IHC
Calc Crossreactivity：Hu
Immunogen：Synthetic peptide corresponding to human REVB at C-terminal (KLH).
