Metabotropic glutamate receptors have been classified into three groups.
In general, class I receptors (mGluR1 and mGluR5) mediate the excitation of neurons, whereas activation of class II (mGluR2 and mGluR3) and class III (mGluR4a, mGluR7a, mGluR7b and mGluR8) results in a depression of synaptic transmission.
Class I mGluRs are localized in the postsynaptic membrane and are positively coupled to phospholipase C (PLC).
Class II and class III mGluRs are localized to the presynaptic membrane and are negatively coupled to adenylate cyclase.
It has been speculated that mGluR2 and/or mGluR3 may play a role in the modulation of the mossy terminal function.
Applications:Suitable for use in Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Immunohistochemistry (Formalin fixed paraffin embedded): 4ug/mlOptimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for at least 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, 0.09% sodium azide.
Specificity：Recognizes human GRM2. Species sequence homology: Mouse (94/100%) and rat (94/100%).
Isotype：IgG
Calc Applications Abbrev：IHC
Calc Crossreactivity：Hu
Immunogen：Synthetic peptide corresponding to extracellular domain of human GRM2 at N-terminal (KLH).
