Met, an HGF Receptor/Met type protein kinase, is a cell-surface proto-oncogene that mediates the biological activities of hepatocyte growth factor.
The protein is a disulfide-linked heterodimer comprised of two subunits: a 50kD extracellular alpha subunit and a membrane-spanning 145kD beta subunit that binds ligand.
Met is an important regulator of cell proliferation and differentiation, organ regeneration, embryogenesis, and tumorogenesis.
Constitutive activation mutations of the met gene lead to many cancers, particularly renal papillary carcinoma.
Applications:Suitable for use in Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Immunohistochemistry (Formalin fixed paraffin embedded): 15ug/mlOptimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for at least 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in 10mM PBS, 1% BSA, pH 7.4, 0.09% sodium azide.
Specificity：Recognizes human MET.
Isotype：IgG
Calc Applications Abbrev：IHC
Calc Crossreactivity：Hu
Immunogen：Synthetic peptide corresponding to human MET at C-terminal.
