Melanoma gp100 a melanosomal matrix protein whose expression is closely correlated with cellular melanin content and which is a frequent melanoma tumor antigen recognized by cytotoxic T lymphocytes.
It is a likely candidate gene for some cases of human oculocutaneous albinism not associated with known albinism loci.
The gp100 protein is the most abundant glycoprotein in nucleated mammalian cells.
The gp100 antigen is highly expressed in melanocyte cells, and recognized by cytotoxic T lynphocytes.
The gp100 protein is known to initiate cellular immune response through the interaction with mature dendritic cells (DCs).
GP100/PMel17 is a melanoma differentiation antigen, which is observed as the target of tumor infiltrating lymphocytes (TIL) and has therefore been proposed as an immunotherapeutic agent in malignant melanoma.
Applications:Suitable for use in Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Immunohistochemistry (Formalin-fixed, paraffin-embedded): 5ug/ml Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for at least 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Purified
Purity：Purified
Form：Supplied as a liquid in 20mM Tris-HCl, pH 8.0, 20mg/ml BSA, 0.05% sodium azide.
Specificity：Recognizes human SILV.
Isotype：IgG
Calc Applications Abbrev：IHC
Calc Crossreactivity：Hu
Immunogen：Synthetic peptide corresponding to the C-terminal sequence of human melanosome/gp100.
