Lamins are structural protein components of the nuclear lamina, a protein network underlying the inner nuclear membrane that determines nuclear shape and size.
There are three types of lamins, A,B and C.The lamin A/C (LMNA) gene contains 12 exons.
Alternative splicing within exon 10 gives rise to two different mRNAs that code for pre-lamin A and lamin C.
Lamin A/C mapped to 1q21.2-q21.3 and mutations in this gene cause a variety of human diseases including Emery-Dreifuss muscular dystrophy, dilated cardiomyopathy, and Hutchinson-Gilford progeria syndrome.
Lamin A/C deficiency is thus associated with both defective nuclear mechanics and impaired mechanically activated gene transcription.
Applications:Suitable for use in Immunofluorescence, Western Blot and Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Immunohistochemistry (Formalin fixed paraffin embedded): 1:50Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for at least 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ul
Host：rabbit
Source Antibody：mouse
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH7.2, 0.09% sodium azide, 50% glycerol.
Specificity：Recognizes mouse LMNA. Species sequence homology: human
Isotype：IgG
Calc Applications Abbrev：IF IHC WB
Calc Crossreactivity：Mo
Immunogen：Recombinant corresponding to mouse LMNA at C-terminal.
