Interleukin 7 Receptor (IL7R) is a receptor for interleukin 7 (IL7).
The function of IL7R requires the interleukin 2 receptor, gamma chain (IL2RG), which is a common gamma chain shared by the receptors of various cytokines, including interleukine 2, 4, 7, 9, and 15.
This protein has been shown to play a critical role in the V(D)J recombination during lymphocyte development.
This protein is also found to control the accessibility of the TCR gamma locus by STAT5 and histone acetylation.
Knockout studies in mice suggested that blocking apoptosis is an essential function of this protein during differentiation and activation of T lymphocytes.
The functional defects in this protein may be associated with the pathogenesis of the severe combined immunodeficiency (SCID).
Applications:Suitable for use in ELISA, Western Blot and Immunohistochemistry.
Other applications not tested.
Recommended Dilution:y:ELISA: 1:100,000 Western Blot: 1:1000-1:10,000Immunohistochemistry (Formalin-fixed, paraffin-embedded): 5ug/ml Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for at least 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ug
Host：rabbit
Source Antibody：mouse
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in 0.02M potassium phosphate, 0.15M sodium chloride, pH 7.2, 0.01% sodium azide.
Specificity：Recognizes mouse IL7R when phosphorylated at Try449. Species sequence homology: Human and rat.
Isotype：IgG
Calc Applications Abbrev：E IHC WB
Calc Crossreactivity：Mo
Immunogen：Synthetic phosphopeptide corresponding to residues near Tyr449 of mouse IL-7 protein.
