The protein encoded by this gene is a nuclear transcription factor which binds DNA as a homodimer.
The encoded protein controls the expression of several genes, including hepatocyte nuclear factor 1 alpha, a transcription factor which regulates the expression of several hepatic genes.
This gene may play a role in development of the liver, kidney, and intestines.
Mutations in this gene have been associated with monogenic autosomal dominant non-insulin-dependent diabetes mellitus type I.
Alternative splicing of this gene results in multiple transcript variants.
Applications:Suitable for use in ELISA, Western Blot and Immunohistochemistry.
Other applications not tested.
Recommended Dilution:ELISA: 1:32,000Western Blot: 0.1-0.5ug/mlImmunohistochemistry (FFPE): 2ug/ml Requires HIER citrate buffer, pH 6.0Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
Host：goat
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in TBS, pH 7.3, 0.5% BSA, 0.02% sodium azide.
Specificity：Recognizes human HNF4A. Species Crossreactivity: monkey, bat, canine, hamster, equine, porcine, rabbit.
Isotype：IgG
Calc Applications Abbrev：E IHC WB
Calc Crossreactivity：Ca Eq Hm Hu Mk Po Rb
Immunogen：Synthetic peptide corresponding to RLSKTLVDMDMADY-C from the N-terminal of human HNF4A. Epitope: 2-15
