Beta1 subunit of guanylate cyclase is a heterodimeric protein consisting of an alpha subunit and a beta subunit linked by disulfide bonds.
Guanylate cyclase functions as the main receptor for nitric oxide, whereupon it catalyzes the conversion of GTP to the second messenger cGMP.
cGMP mediates the vasodilator capacity of NO, and is important in modulating other vascular functions, including cellular proliferation, apoptosis, migration and extracellular matrix production.
Guanylate cyclase beta1 has recently been shown to be upregulated in mononuclear cells from patients with erectile dysfunction.
Applications:Suitable for use in Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Immunohistochemistry (Formalin fixed paraffin embedded): 10ug/mlOptimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for at least 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in 10mM PBS, pH 7.4, BSA, sodium azide.
Specificity：Recognizes human GUCY1B3. Species sequence homology: Mouse and rat.
Isotype：IgG
Calc Applications Abbrev：IHC
Calc Crossreactivity：Hu
Immunogen：Synthetic peptide corresponding to aa189-207 of human GUCY1B3.
