Its function is not clear, but it has been demonstrated that the human Elongator facilitates transcription by RNA polymerase II in a chromatin- and acetyl-CoA-dependent manner.
IKBKAP.
IKBKAP was originally described as a scaffold protein of the IKK complex involved in NF-kB activation, but this role has since been disputed.
IKBKAP is a component of the RNA polymerase II elongator complex which has histone acetyltransferase activity and is involved in transcriptional elongation.
Gene defects are a cause of familial dysautonomia, also known as Riley-Day syndrome.
Affected individuals show a variety of symptoms such as decreased sensitivity to pain and temperature, cardiovascular instability, pneumonia and gastrointestinal dysfunction.
Applications:Suitable for use in ELISA, Western Blot and Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:1000Immunohistochemistry (Formalin fixed paraffin embedded): 20ug/mlOptimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for at least 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, 0.02% sodium azide.
Specificity：Recognizes human IKBKAP.
Isotype：IgG
Calc Applications Abbrev：E IHC WB
Calc Crossreactivity：Hu
Immunogen：Synthetic peptide corresponding to aa148-161 from human IKBKAP (KLH).
