Caspases mediate essential key proteolytic events in inflammatory cascades and the apoptotic cell death pathway.
Caspase 12 is involved in the apoptosis triggered by a stress on the endoplasmic reticulum.
Caspase-12 is colocalized to the ER with several proteins that are involved in Alzheimer's disease including gamma-secretase presenilin and beta-amyloid precursor protein (APP).
Caspase-12 mediates cytotoxicity induced by amyloid-beta.
Caspase 12 activation results in cell death in the absence of the cytochrome c-dependent pathway.
Recently caspase-12 has been suggested to affect signaling pathways linking some G-protein coupled receptors to alphaIIbbeta3 activation.
Caspase-12 is ubiquitously expressed in mouse tissues.
Applications:Suitable for use in Western Blot and Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Immunohistochemistry (Formalin fixed paraffin embedded): 10ug/ml Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for at least 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ug
Host：rabbit
Source Antibody：mouse
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, 0.02% sodium azide.
Specificity：Recognizes mouse CASP12. Species sequence homology: Human and rat.
Isotype：IgG
Calc Applications Abbrev：IHC WB
Calc Crossreactivity：Mo
Immunogen：Synthetic peptide corresponding to aa2-17 of mouse CASP12 (KLH).
