Beta-thromboglobulin (β-thromboglobulin, also called Pro-Platelet basic protein or BTG) is a protein that is stored in alpha-granules of platelets and released in large amounts after platelet activation.[1] It is a type of Chemokine (C-X-C motif) ligand 7.[2] Beta-Thromboglobulin is a chemoattractant, strongly for fibroblasts and weakly for neutrophils.
It is a stimulator of mitogenesis, extracellular matrix synthesis, glucose metabolism, and plasminogen activator synthesis in human fibroblasts.[1] Beta-Thromboglobulin also affects megakaryocyte maturation, and thus helps in regulating platelet production.[1] Levels of Beta-Thromboglobulin is used to index platelet activation.
It is measured by ELISA in blood plasma or urine, and often in conjunction with Platelet factor 4)[1] It is elevated in diabetes mellitus.[3]
Applications:Suitable for use in ELISA and Immunoprecipitation.
Other applications not tested.
Recommended Dilution:Optimal dilutions to be determined by the researcher.
Storage and Stability:Lyophilized powder may be stored at -20°C.
Stable for 12 months at -20°C.
Reconstitute with sterile ddH2O.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Reconstituted product is stable for 12 months at -20°C.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Further dilutions can be made in assay buffer.
仕様
Size：1ml
Host：rabbit
Source Antibody：human
Grade：Serum
Purity：Serum
Form：Supplied as a lyophilized powder, 1mg/ml sodium azide. Reconstitute in 1ml sterile ddH2O. Dilute further in PBS, pH 7.2.
Specificity：Recognizes human beta-Thromboglobulin.
Isotype：IgG
Calc Applications Abbrev：E IP
Calc Crossreactivity：Hu
Immunogen：Highly purified human beta-Thromboglobulin isolated from platelets
