The protein encoded by this gene is an enzymatic component of the tricarboxylic acid (TCA) cycle, or Krebs cycle, and catalyzes the formation of L-malate from fumarate.
It exists in both a cytosolic form and an N-terminal extended form, differing only in the translation start site used.
The N-terminal extended form is targeted to the mitochondrion, where the removal of the extension generates the same form as in the cytoplasm.
It is similar to some thermostable class II fumarases and functions as a homotetramer.
Mutations in this gene can cause fumarase deficiency and lead to progressive encephalopathy.
Applications:Suitable for use in Immunoelectrophoresis, RID, ELISA, Western Blot and Inhibition.
Other applications have not been tested.
Recommended Dilutions: Optimal dilutions to be determined by the researcher.
Storage and Stability:Lyophilized powder may be stored at -20°C.
Stable for 12 months at -20°C.
Reconstitute with sterile ddH2O.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Reconstituted product is stable for 12 months at -20°C.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Further dilutions can be made in assay buffer.
仕様
Size：1ml
Host：rabbit
Source Antibody：porcine
Grade：Highly Purified
Purity：Purified by ammonium sulphate precipitation and ion exchange chromatography.
Form：Supplied as a lyophilized powder from PBS, pH 7.2. No preservatives added. Labeled with Biotin. Reconstitute with 1ml sterile ddH2O.
Specificity：Recognizes Fumerase.
Isotype：IgG
Calc Applications Abbrev：E WB
Immunogen：Fumarase isolated and purified from porcine heart.
