84-1195-85　Integrin alpha 11 100ug　I7661-37U1

特徴

• Integrin a11 ( ITGA11) is a 155-160kD member of the integrin alpha chain family of molecules.
• It preferentially forms a cell surface heterodimer with b1 Integrin.
• In particular, it is further classified as a collagen-binding group member, showing a preference for binding to collagen I and II, plus group A Streptococcal Scl1 protein.
• ITGA11 is expressed by embryonic mesenchymal cells in areas that incorporate collagen during development.
• In adult tissue, fibroblasts express ITGA11, and a collagen:ITGA11 interaction likely contributes to the formation of myofibroblasts.
• Mature mouse ITGA11 is an 1166aa type I transmembrane glycoprotein.
• It contains a large 1119aa extracellular domain (ECD) aa23-1141 plus a short 24aa cytoplasmic region.
• The ECD shows 7x60aa FG-Gap repeats that generate b-propellers aa24-650 with an intervening I domain that binds collagen aa164-345.
• There is one potential splice variant that shows an eight aa substitution for aa89-119 coupled to a seven aa insertion after Gly690.
• Over aa23-1141, mouse ITGA11 shares 95-90aa identity with rat and human ITGA11, respectively.
• Applications:Suitable for use in Western Blot and Immunocytochemistry.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1ug/mlImmunocytochemistry: 5-15ug/mlOptimal dilutions to be determined by the researcher.
• Storage and Stability:Lyophilized powder may be stored at -20°C.
• Stable for 12 months at -20°C.
• Reconstitute with PBS.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Reconstituted product is stable for 12 months at -20°C.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
• Further dilutions can be made in assay buffer.