84-1195-62　CD79b (CD79b Antigen, CD79b Molecule Immunoglobulin-associated beta, CD79b Protein, B Cell Antigen Receptor Complex-associated Protein beta Chain, B Cell-specific Glycoprotein B29, B29, Ig-beta, IGB, Immunoglobulin-associated B29 Protein) 100ug　C2431-06L1

特徴

• CD79B is a 36-40kD member of the Ig-Superfamily.
• It is expressed on B cells, and forms a covalent heterodimer with 44-49kD CD79A.
• This complex interacts noncovalently with membrane Ig, forming the B cell antigen receptor.
• Within this complex, membrane Ig detects antigen while CD79A:B initiates signaling.
• Mature human CD79B is a 201aa type I tranamembrane glycoprotein (aa29-229).
• It contains an extracellular region with one V-type Ig-like domain (aa38-138) and an ITAM-containing cytoplasmic domain (aa181-229).
• There is an alternative splice form that shows a deletion of aa41-144 and appears after B cell activation.
• Human CD79A and B share only 26aa identity.
• Over aa29-159, human CD79B shares 54aa identity with mouse CD79B.
• Applications:Suitable for use in Flow Cytometry and Western Blot.
• Other applications not tested.
• Recommended Dilution:Flow Cytometry: 2.5ug labels 10e6 cellsWestern Blot: 0.5ug/mlOptimal dilutions to be determined by the researcher.
• Storage and Stability:Lyophilized powder may be stored at -20°C.
• Stable for 12 months at -20°C.
• Reconstitute with sterile PBS.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Reconstituted product is stable for 12 months at -20°C.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
• Further dilutions can be made in assay buffer.