84-1195-59　Calsyntenin-2 (Calsyntenin 2, Alcadein-gamma, Alc-gamma, CLSTN2, CS2) 100ug　C1036-36

特徴

• Calsyntenin-2 (CS-2) is a 120-135kD member of the Alcadein family of molecules.
• It is expressed in the ER/Golgi, and the plasma membranes of almost all neurons.
• It is a calcium-binding protein that interacts with APP and X11L.
• In this regard, it appears to regulate APP cleavage and gene activation, and likely impacts post-synaptic signaling.
• Notably, when cleaved in a manner similar to APP, its intracellular fragment antagonizes AICD gene activation.
• Mature human CS-2 is a 935aa type I transmembrane protein.
• It contains two cadherin domains aa44-280 in its extracellular region aa21-831 and a 103aa cytoplasmic tail.
• Proteolytic cleavage by ADAM10 occurs between His803 and Leu804 to generate a 105-110kD extracellular fragment.
• Additional processing of the transmembrane fragment by g-secretase creates a 3kD fragment aa804-834 plus a 25kD cytoplasmic protein.
• Potential isoform variants show a premature truncation after Gln608, and the use of an alternative start site at Met409.
• Over aa21-834, human CS-2 shares 95aa identity with mouse CST-2.
• Applications:Suitable for use in Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Immunohistochemistry: 5-15ug/mlOptimal dilutions to be determined by the researcher.
• Storage and Stability:Lyophilized powder may be stored at -20°C.
• Stable for 12 months at -20°C.
• Reconstitute with PBS.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Reconstituted product is stable for 12 months at -20°C.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
• Further dilutions can be made in assay buffer.