84-1195-40　PZR, Phosphorylated (Tyr263) (Myelin Protein Zero-like Protein 1, Protein Zero-related, MPZL1, UNQ849/PRO1787) 100ul　P9580-20

特徴

• PZR (Protein zero related) is an immunoglobulin superfamily protein that specifically binds the tyrosine phosphatase SHP-2 through its intracellular immunoreceptor tyrosine-based inhibitory motifs (ITIMs) (1,2).
• PZR is phosphorylated by c-Src, c-Fyn, c-Lyn, Csk, and c-Abl (3).
• PP1, a Src family kinase inhibitor, inhibits PZR phosphorylation (4,5).
• There are three alternatively spliced isoforms designated as PZR, PZRa, and PZRb; both PZRa and PZRb lack ITIMs (6,7).
• PZR is a main receptor of ConA and has an important role in cell signaling via c-Src (4).
• PZR is expressed in many cell types and is localized to cell contacts and intracellular granules in BAECs and mesothelioma (REN) cells.
• Recently, PZR has been implicated as a cell adhesion protein that may be involved in SHP-2-dependent signaling at interendothelial cell contacts (3).
• Hypertyrosine phosphorylation of PZR was observed during embryogenesis in a mouse model of Noonan Syndrome (8).
• Applications:Suitable for use in Western Blot and Immunoprecipitation.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:1000Immunoprecipitation: 1:50Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.